導師簡介
姓名：徐鈞 性別：男 政治面貌：中共黨員
學歷：研究生 學位：博士 職稱：主任醫(yī)師
博、碩導師：博士生導師 本崗位工作年數(shù)：33年
研究方向：肝移植的臨床及基礎研究
榮譽稱號：享受國務院特殊津貼專家，山西名醫(yī)，山西省學術技術帶頭人，三晉英才高端領軍人才，省委聯(lián)系高級專家。
學術任職：中華醫(yī)學會外科分會微創(chuàng)外科學組委員，中華醫(yī)學會器官移植學分會委員，中國醫(yī)師協(xié)會外科分會常務委員，中國醫(yī)師協(xié)會器官移植醫(yī)師分會委員，山西省抗癌協(xié)會理事長，山西省醫(yī)學會常務理事，山西省醫(yī)學會微創(chuàng)外科專業(yè)委員會主任委員，山西省醫(yī)學會普外科專業(yè)委員會主任委員，山西省醫(yī)學會器官移植專業(yè)委員會副主任委員，山西省醫(yī)師協(xié)會內鏡醫(yī)師分會普外科學組主任委員。
近五年承擔科研課題情況：
1、消化系疾病及器官移植山西省重點實驗室，山西省科技廳，202204010931008，300萬元，2023.1-2024.12
2、國家自然科學基金面上項目，82072737，circRNA0007766/miR4492/MET/PI3K-Akt通路調控食管胃結合部腺癌增殖和侵襲的分子機制研究，2021/01-2024/12，55萬元，主持。
3、山西省科學技術廳，中央引導地方專項，YDZJSX2021B012，肝移植術后免疫排斥反應評估研究科技創(chuàng)新基地，2021/08-2023/12，90萬元，在研。
4、山西省衛(wèi)生健康委，2020085，子宮內膜間充質干細胞通過gp130-Src-YAP通路調控肝移植術后免疫排斥反應的機制研究，2021/01-2022/12,3萬元，主持。
5、山西省衛(wèi)生健康委員會，創(chuàng)新團隊，2020TD08，肝臟移植研究科技領軍團隊，2021-01至2023-12，20萬元，在研，主持。
代表性論著及近五年的代表性論文（限10項以內）：
Jia Yao，Tian Liu，Qiang ZhaoYaqiu Ji，Jinjia Bai，Han Wang，Ruoyu Yao，Xiaoshuang Zhou，Yu Chen，Jun Xu. Genetic landscape and immune mechanism of monocytes associated with the progression of acuteonchronic liver failure. Hepatology Internationa.2023 Jun;17(3)
Zihe Zhu, Qianqian Zhang, Lixin Liu, Jun Xu. Human umbilical cord Mesenchymal stem cell's cultivation of treatment liver diseases. Curr Stem cell Res Ther. 2022. Jun 23(IF=3.758)
Lai Z, Chen Z, Zhang A, Huo C and Xu J (2022) The Gut Microbiota in Liver Transplantation Recipients During the Perioperative Period. Front. Physiol. 2022;13(IF=4.755)
Gaopeng Li, Guoliang Wang, Fenqing Chi, Yuqi Jia, Xi Wang, Quankai Mu, Keru Qin, Xiaoxia Zhu, Jing Pang, Baixue Xu, Guangen Feng, Yuhu Niu, Tao Gong, Hongwei Zhang, Xiushan Dong, Ting Liu, Jinfeng Ma, Zefeng Gao, Kai Tao, Feng Li, Jun Xu*, Baofeng Yu*. Higher postoperative plasma EV PD- L1 predicts poor survival in patients with gastric cancer. Journal for Immuno Therapy of Cancer . doi:10.1136/ jitc-2020-002218.
Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu*, Jun Xu* and Jun Xie*. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics Chromatin. 2021 Dec 4;14(1):52.
Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang and Jun Xu. KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway. Cell Biosci (2021) 11:73.
Yarong Guo, Jun Xu, Qiang Du, Yihe Yan, David A. Geller. IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin.Transl Oncol 2021 Jun;14(6).
Jia Yao, Zhou X, Yuan L, Niu LY, Zhang A, Shi H, Duan Z, Xu J*. Prognostic value of the third lumbar skeletal muscle mass index in patients with liver cirrhosis and ascites. Clin Nutr. 2020 Jun;39(6):1908-1913.
Li Zhang, Juan Zhang, Dandan Li, Ping Yan, Ajab Khan, Xueqin Liu, Lei Wang, Zhizhen Liu, Jianbing Mu, Jun Xu, Bo Niu*, Jun Xie*. Excessive apoptosis and ROS induced by ethionine affects neural cells viability and differentiation[J]. Acta Biochimica et Biophysica Sinica 2020, Oct, 10;gmaa093.
Meng T, Fan B, Li Q, Peng X, Xu J, Zhang R. Matrix metalloproteinase-initiated aggregation of melanin nanoparticles as highly efficient contrast agent for enhanced tumor accumulation and dual-modal imaging.J Mater Chem B 2020 Oct 09.
教學科研
